[Study of the contractile function of the gallbladder using cholescintigraphy]

Area of Science:

• Hepatobiliary imaging
• Gastroenterology
• Nuclear medicine

Background:

• Gall bladder motor function is crucial for bile secretion.
• Chronic cholecystitis and hepatitis can impair gall bladder motility.
• Cholescintigraphy is a valuable tool for assessing gall bladder function.

Purpose of the Study:

• To evaluate gall bladder motor activity in patients with chronic cholecystitis and chronic hepatitis.
• To compare the gall bladder's response to different cholagogic stimulators.
• To develop a method for analyzing gall bladder contraction phases and reaction times.

Main Methods:

• Utilized cholescintigraphy with technetium-99m labeled iminodiacetic acid (99m Tc-HIDA).
• Studied 57 patients with chronic cholecystitis/hepatitis and 9 healthy controls.
• Performed comparative analysis of activity-time curves from gall bladder contours and zones.

Main Results:

• Identified differential gall bladder responses to intravenous cholecystokinin and a cholagogic breakfast.
• Developed a processing method to quantify gall bladder contraction phases during emptying.
• Determined true latent periods and primary reaction periods of the biliary apparatus post-stimulus.

Conclusions:

• Cholescintigraphy with 99m Tc-HIDA effectively differentiates gall bladder motor responses.
• The developed analysis method provides quantitative insights into biliary apparatus function.
• This approach aids in diagnosing and understanding motility disorders in hepatobiliary diseases.