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Study Preregistration: Measuring What Matters: Development and Dissemination of a Core Outcome Set for Pediatric
Suneeta Monga1, Riddhi Desai2, Samantha J Anthony1
1Hospital for Sick Children, and the University of Toronto, Ontario, Canada.
Summary
Standardizing outcome measurement in pediatric anxiety clinical trials is crucial for improving research translation. The COMPACT Initiative will develop a Core Outcome Set (COS) for consistent measurement in pediatric anxiety research.
Area of Science:
- Child and Adolescent Psychiatry
- Clinical Psychology
- Health Services Research
Background:
- Pediatric anxiety disorders (AD) significantly impact children's lives.
- Current research faces challenges due to inconsistent outcome selection, measurement, and reporting.
- Standardization is needed to improve the translation of research findings into clinical practice.
Purpose of the Study:
- To develop a harmonized, evidence- and consensus-based Core Outcome Set (COS) for pediatric anxiety clinical trials.
- To ensure the COS is meaningful to youth and families.
- To address heterogeneity in outcome measurement in pediatric AD research.
Main Methods:
- The study outlines the development of a Core Outcome Set (COS).
- This involves creating a minimal set of outcomes for consistent measurement and reporting in clinical trials.
- The initiative aims for an evidence- and consensus-based approach.
Main Results:
- The Core Outcomes and Measures in Pediatric Anxiety Clinical Trials (COMPACT) Initiative is established.
- The initiative will develop a standardized Core Outcome Set (COS).
- This COS will be used in future pediatric anxiety clinical trials.
Conclusions:
- A standardized Core Outcome Set (COS) is essential for advancing pediatric anxiety research.
- The COMPACT Initiative's COS will improve consistency and comparability across studies.
- This standardization will facilitate the translation of research into effective clinical practice for pediatric anxiety.
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