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Updated: Jul 28, 2025

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Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses
Published on: December 29, 2015
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[Yezo virus and emerging orthonairovirus diseases]
Keita Matsuno1,2,3
1Okazaki National Research Institutes.
Uirusu
|May 28, 2023
Summary
A novel tick-borne virus, Yezo virus, has been identified in Japan causing acute febrile illness. Ongoing surveillance is crucial for understanding and monitoring this emerging infectious disease.
Area of Science:
- Virology
- Emerging infectious diseases
- Tick-borne illnesses
Context:
- A new etiological agent, Yezo virus, was identified in Hokkaido, Japan, in 2019.
- Seven cases of Yezo virus infection were detected between 2014 and 2020 through surveillance.
- Yezo virus belongs to the genus Orthonairovirus, family Nairoviridae, and the Sulina genogroup.
Purpose:
- To report the discovery and initial characterization of Yezo virus.
- To classify Yezo virus within the Orthonairovirus genus and Sulina genogroup.
- To highlight the relationship of Yezo virus to other nairoviruses and its potential public health significance.
Summary:
- Yezo virus is an emerging tick-borne pathogen causing acute febrile illness in Japan.
- It is phylogenetically related to Sulina and Tamdy genogroup viruses, distinct from other known orthonairoviruses.
- The virus was identified following passive and retrospective surveillance of febrile illness cases.
Impact:
- This discovery expands the known diversity of Orthonairovirus pathogens.
- It underscores the importance of monitoring emerging tick-borne diseases.
- Further research is needed to understand the epidemiology and clinical spectrum of Yezo virus infections.
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