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Updated: Jul 28, 2025
12:20
Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses
Published on: December 29, 2015
21.5K
Summary
B virus (herpesvirus simiae) is a rare but severe neuropathogenic infection primarily found in macaque monkeys. This summary details its virology, human cases, and genotypes, highlighting the ongoing risk.
Area of Science:
- Virology
- Infectious Diseases
- Primate Health
Context:
- B virus (herpesvirus simiae) naturally infects macaque monkeys.
- Human infections are rare, historically documented in laboratory workers and breeders in North America and the UK.
- Recent cases in Japan (2019) and China (2021) mark the first reports since 1997.
Purpose:
- To describe the virological properties of B virus.
- To present findings from documented human B virus disease cases.
- To analyze the genotype of the B virus strains.
Summary:
- B virus exhibits extreme neuropathogenicity in humans.
- Viral factors contributing to human neuropathogenicity remain unidentified.
- While contact with wild macaques is not reported, the possibility of infection cannot be excluded.
Impact:
- Provides a comprehensive overview of B virus, crucial for risk assessment in primate handlers.
- Enhances understanding of a rare but potentially devastating zoonotic disease.
- Informs public health strategies for preventing and managing B virus infections.
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