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Updated: Jul 28, 2025

Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses
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Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses

Published on: December 29, 2015

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[B virus]

    Uirusu
    |May 28, 2023
    PubMed

    Insights

    B virus (herpesvirus simiae) is a rare but severe neuropathogenic infection primarily found in macaque monkeys. This summary details its virology, human cases, and genotypes, highlighting the ongoing risk.

    Area of Science:

    • Virology
    • Infectious Diseases
    • Primate Health

    Context:

    • B virus (herpesvirus simiae) naturally infects macaque monkeys.
    • Human infections are rare, historically documented in laboratory workers and breeders in North America and the UK.
    • Recent cases in Japan (2019) and China (2021) mark the first reports since 1997.

    Purpose:

    • To describe the virological properties of B virus.
    • To present findings from documented human B virus disease cases.
    • To analyze the genotype of the B virus strains.

    Summary:

    • B virus exhibits extreme neuropathogenicity in humans.
    • Viral factors contributing to human neuropathogenicity remain unidentified.
    • While contact with wild macaques is not reported, the possibility of infection cannot be excluded.

    Impact:

    • Provides a comprehensive overview of B virus, crucial for risk assessment in primate handlers.
    • Enhances understanding of a rare but potentially devastating zoonotic disease.
    • Informs public health strategies for preventing and managing B virus infections.

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