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Related Experiment Video

Updated: Jul 28, 2025

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

Understanding inequities in precision oncology diagnostics.

Ritika Dutta^1,2, Mounica Vallurupalli^3,4, Quinn McVeigh^3,4

¹Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

|May 29, 2023

Summary

This summary is machine-generated.

Precision oncology uses molecular diagnostics to find cancer drivers. However, advanced biomarker testing like next-generation sequencing (NGS) can worsen healthcare disparities, requiring multidisciplinary solutions.

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Area of Science:

Oncology
Molecular Diagnostics
Genomics

Background:

Precision oncology relies on identifying targetable driver mutations.
Advanced molecular diagnostic technologies, including next-generation sequencing (NGS), are crucial for personalized cancer care.
The implementation of these advanced technologies may inadvertently widen existing healthcare disparities.

Purpose of the Study:

To summarize data on the utilization patterns of advanced biomarker testing.
To highlight disparities in accessing and utilizing next-generation sequencing (NGS) for patient care.
To propose multidisciplinary strategies for addressing inequities in precision oncology.

Main Methods:

Review of data on advanced biomarker testing use patterns.
Analysis of disparities in next-generation sequencing (NGS) access and application.
Formulation of multidisciplinary strategies to mitigate inequities.

Main Results:

Unequal access to and utilization of advanced biomarker testing, including NGS.
Disparities in leveraging NGS data for personalized therapy matching.
Identification of key areas for intervention to improve equity.

Conclusions:

Advanced molecular diagnostics offer significant promise but risk exacerbating healthcare disparities.
Addressing inequities in accessing and utilizing NGS is essential for equitable precision oncology.
Multidisciplinary strategies are proposed to promote equitable biomarker testing and personalized treatment.