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TFEB - at the crossroads of host-pathogen interactions
Keerti1, Aarti Pant1, Ravi Manjithaya1,2
1Autophagy Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, 560064, Karnataka, India.
Journal of Cell Science
|May 30, 2023
Summary
The transcription factor TFEB regulates host defense against intracellular pathogens by controlling autophagy and lysosomal pathways. Its precise role in infection is complex, impacting pathogen survival and host immunity.
Area of Science:
- Host-pathogen interactions
- Molecular immunology
- Cellular microbiology
Background:
- Host defense relies on dynamic interactions with pathogens.
- Autophagy and phagocytosis are key pathways for eliminating intracellular pathogens.
- The transcription factor TFEB influences autophagy-lysosomal function and immune responses.
Purpose of the Study:
- To review the multifaceted role of TFEB in host-pathogen interactions.
- To elucidate the molecular mechanisms governing TFEB's function during intracellular infections.
- To assess TFEB as a potential therapeutic target for infectious diseases.
Main Methods:
- Literature review of studies on TFEB, host-pathogen interactions, and autophagy-lysosomal pathways.
- Analysis of evidence regarding TFEB translocation and gene activation during infection.
- Examination of pathogen strategies to modulate TFEB activity.
Main Results:
- TFEB translocates to the nucleus upon infection, activating autophagy-lysosomal and inflammatory pathways.
- Pathogens can manipulate TFEB, either restricting its activity or utilizing its function for replication.
- The precise outcome of TFEB modulation by pathogens remains unclear.
Conclusions:
- TFEB plays a critical but complex role in the host's response to intracellular pathogens.
- Understanding TFEB regulation is crucial for developing new therapeutic strategies.
- TFEB represents a promising, yet complex, target for clinical intervention in infectious diseases.
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