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Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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Diabetes Mellitus: Type 2 and Gestational01:22

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Diabetes Mellitus: Overview and Type I Subtype01:22

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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
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Diabetes: Symptoms, Diagnosis, and Complications01:15

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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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Carbohydrate Metabolism01:36

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Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
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Insulin Secretory Vesicles01:05

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Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
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Updated: Jul 28, 2025

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
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Sigmoid volvulus and diabetes mellitus.

Esra Disci1, Rifat Peksoz2, Sabri Selcuk Atamanalp3

  • 1Esra Disci, MD, Associate Professor Department of General Surgery, Faculty of Medicine, Ataturk University, Erzurum, Turkey.

Pakistan Journal of Medical Sciences
|May 30, 2023
PubMed
Summary

Diabetes mellitus (DM) significantly increases sigmoid volvulus (SV) mortality. While the exact link is unclear, DM appears to worsen SV prognosis, highlighting the need for early diagnosis and treatment in affected patients.

Keywords:
ComorbidityDiabetes mellitusSigmoid volvulus

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Area of Science:

  • Gastroenterology
  • Endocrinology
  • Surgical Pathology

Background:

  • Diabetes mellitus (DM) is present in 15.7% of sigmoid volvulus (SV) cases, but the underlying pathophysiology remains unclear.
  • Understanding the association between DM and SV is crucial for improving patient outcomes.

Purpose of the Study:

  • To evaluate the association between diabetes mellitus and sigmoid volvulus.
  • To investigate the impact of DM on SV prognosis.

Main Methods:

  • Retrospective and prospective analysis of 1,051 patients treated between 1966 and 2022.
  • Comprehensive literature review of 56 years of worldwide data from PubMed and Web of Science.

Main Results:

  • DM prevalence was higher in SV patients (15.7%) compared to the general population (8.3%).
  • SV and DM comorbidity was lower in the study cohort (2.9%) than global data (15.7%).
  • Mortality rate was significantly higher in SV patients with DM (28.6%) versus those without (7.8%).

Conclusions:

  • Diabetes mellitus appears to worsen the prognosis of sigmoid volvulus.
  • Early diagnosis and prompt treatment are critical for managing SV patients with DM to improve outcomes.