Related Experiment Video
Updated: Jul 28, 2025
10:40
CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
Published on: April 25, 2022
2.4K
MicroRNA-372 acts as a double-edged sword in human cancers
Fatemeh Tajik1, Fatemeh Alian2, Mohammad Yousefi3
1Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Heliyon
|May 30, 2023
Summary
MicroRNAs (miRNAs) regulate gene expression and cancer. This study explores microRNA-372 (miR-372) roles in various cancers and its potential as a diagnostic and therapeutic target.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- MicroRNAs (miRNAs) are endogenous non-coding RNAs regulating gene expression post-transcriptionally.
- miRNAs function as oncogenes or tumor suppressors, influencing cancer pathophysiology.
- Aberrant expression of microRNA-372 (miR-372) is observed in various human malignancies.
Purpose of the Study:
- To investigate the multifaceted roles of miR-372 in carcinogenesis.
- To analyze the involvement of LncRNA/CircRNA-miRNA-mRNA signaling pathways in cancer.
- To evaluate the prognostic, diagnostic, and therapeutic potential of miR-372.
Main Methods:
- Literature review and analysis of existing studies on miR-372.
- Examination of miRNA expression patterns in different cancer types.
- Investigation of regulatory networks involving long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and miR-372.
Main Results:
- miR-372 exhibits dual roles, acting as both an oncogene and a tumor suppressor in different cancers.
- Dysregulation of miR-372 is implicated in the development and progression of numerous malignancies.
- Specific LncRNA/CircRNA-miRNA-mRNA pathways involving miR-372 are identified in various cancers.
Conclusions:
- miR-372 is a significant player in cancer development and progression.
- Understanding miR-372 regulatory networks offers insights into cancer biology.
- miR-372 holds promise as a biomarker for cancer prognosis and diagnosis, and as a therapeutic target.
More Related Videos
08:40Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
Published on: April 6, 2012
17.7K
07:19Identifying Targets of Human microRNAs with the LightSwitch Luciferase Assay System using 3'UTR-reporter Constructs and a microRNA Mimic in Adherent Cells
Published on: September 28, 2011
36.3K
Related Concept Videos
01:22MicroRNAs
3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
02:23Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
02:55The Nucleolus
8.9K
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
8.9K
02:39lncRNA - Long Non-coding RNAs
8.7K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.7K
02:23Master Transcription Regulators
7.0K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.0K