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Characteristics of intestinal microbiota in infants with late-onset breast milk jaundice

Qianying Guo1, Xinran Liu1, Mingxuan Cui1

  • 1Department of Clinical Nutrition, Peking University People's Hospital, Beijing, China.

Frontiers in Nutrition
|May 30, 2023
PubMed

Insights

Late-onset breast milk jaundice (LBMJ) in infants is linked to distinct gut microbiota changes. The abundance of Klebsiella bacteria correlates with jaundice severity, suggesting a role in the condition.

Area of Science:

  • Microbiology
  • Neonatal Health
  • Gastroenterology

Background:

  • Late-onset breast milk jaundice (LBMJ) is a condition affecting infants.
  • Understanding the factors contributing to LBMJ is crucial for infant health.
  • The role of the gut microbiota in neonatal conditions is an emerging area of research.

Purpose of the Study:

  • To analyze and compare the intestinal microbiota structure and differences between infants with LBMJ and healthy controls.
  • To identify specific bacterial genera associated with LBMJ.
  • To investigate the correlation between gut microbiota composition and jaundice severity (TcB values).

Main Methods:

  • Fecal samples were collected from 13 LBMJ infants and 13 healthy infants.
  • 16S rRNA sequencing was used to determine intestinal microbiota composition.
  • Analysis included microbiota structure, diversity (alpha and beta), functional characteristics, and correlation with TcB values.

Main Results:

  • No significant differences were found in maternal or neonatal characteristics between groups.
  • Significant differences in intestinal microbiota structure, richness, and diversity were observed between LBMJ and control groups.
  • The genus Klebsiella was significantly enriched in LBMJ infants and positively correlated with transcutaneous bilirubin (TcB) values.

Conclusions:

  • Infants with LBMJ exhibit characteristic alterations in their intestinal microbiota composition.
  • Klebsiella enrichment is closely associated with LBMJ severity, potentially due to increased beta-glucuronidase activity.
  • These findings highlight the potential role of gut microbiota in the pathogenesis of LBMJ.
Abstract

Keywords:
16S rRNAKlebsiellabreastfed infantsintestinal microbiotalate-onset breast milk jaundice

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