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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Circadian Regulation of Metabolism: Commitment to Health and Diseases

Tomoki Sato1, Shogo Sato2

  • 1Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.

Endocrinology
|May 30, 2023
PubMed

Insights

Timing meals correctly is key for metabolic health. Eating at the right time, not just what or how much, helps regulate your body

Area of Science:

  • Chronobiology
  • Metabolic Health
  • Nutritional Science

Background:

  • The circadian clock, regulated by the suprachiasmatic nucleus (SCN), governs daily rhythms in metabolism and endocrine systems.
  • Disrupted circadian rhythms are linked to metabolic diseases like obesity and type 2 diabetes.
  • Metabolic activity and epigenetic factors influence circadian clock function.

Approach:

  • This review synthesizes current research on the interplay between circadian rhythms and metabolic homeostasis.
  • It examines the role of food intake as a potent zeitgeber for circadian clocks.
  • Evidence from basic and translational studies is summarized.

Key Points:

  • The circadian clock is crucial for maintaining metabolic homeostasis.
  • Disruptions from factors like shift work and jet lag increase disease risk.
  • Food intake timing, independent of SCN light cues, significantly impacts metabolic pathways.

Conclusions:

  • Chrononutritional strategies, focusing on meal timing, can improve metabolic health.
  • Restoring circadian control through timed eating promotes health and prevents disease.
  • Understanding this relationship is vital for public health interventions.
Keywords:
chrononutritioncircadian clockgut microbiomemetabolic diseasesmetabolismmulti-tissue communication

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