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PHOTORECEPTOR DAMAGE IN TERSON SYNDROME.

Tomasz Szeligowski1, Dun J Fu1, Noa Fernandez-Ledo1

  • 1Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.

Retina (Philadelphia, Pa.)
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Photoreceptor damage in Terson syndrome, characterized by outer retinal changes, leads to poor visual outcomes. This damage, potentially from intracranial pressure, shows incomplete recovery despite treatment.

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Area of Science:

  • Ophthalmology
  • Neurology

Background:

  • Terson syndrome is associated with subarachnoid hemorrhage.
  • Clinical outcomes in Terson syndrome can be variable.

Purpose of the Study:

  • To describe photoreceptor damage in Terson syndrome.
  • To investigate the cause of inconsistent clinical outcomes in Terson syndrome.

Main Methods:

  • Clinical evaluation of six patients with Terson syndrome.
  • Retinal imaging to assess photoreceptor damage.

Main Results:

  • Consistent outer retinal changes, indicating photoreceptor damage, were observed in 11 eyes.
  • Photoreceptor damage showed poor correlation with intraocular hemorrhage.
  • Retinal abnormalities demonstrated incomplete recovery over 3.5 to 8 years, with variable impact on visual function.

Conclusions:

  • Photoreceptor damage is a distinct manifestation of Terson syndrome.
  • Transient outer retinal ischemia secondary to increased intracranial pressure may cause this damage.