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Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
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Individualizing primary prophylaxis in patients with hemophilia A and B, adherence and new products

Rubén Berrueco1

  • 1Pediatric Hematology Department, Hospital Sant Joan de Déu Barcelona, Universitat de Barcelona. Institut de Recerca Pediàtrica, Hospital San Joan de Déu de Barcelona (IRP-HSJD), Esplugues de Llobregat, Barcelona.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|May 31, 2023
PubMed

The purpose of prophylaxis in hemophilic patients is to prevent bleeding. The latest guidelines of the World Hemophilia Federation recommend that all patients with a severe hemorrhagic phenotype should receive prophylactic treatment, defined as the regular administration of therapeutic products (either factor concentrates or nonfactor replacement treatments). These products are aimed at preserving hemostasis and preventing bleeding, especially into joints. The guidelines also stipulate that prophylaxis should allow patients with hemophilia to lead healthy and active lives, participating in most physical and social activities, similar to the nonhemophilic population.

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