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Correlation between serum laminin level and prognosis of acute heart failure
Xiaoyun Yan1, Jiaqi Ye1, Haixiao Chen1
1Department of General Practice, Affiliated Hospital 2 of Nantong University, Nantong, China.
Insights
Elevated serum laminin (LN) levels are linked to major adverse cardiovascular events (MACE) in patients hospitalized with acute heart failure (AHF). This finding suggests LN may serve as a valuable biomarker for predicting poor AHF prognosis.
Area of Science:
- Cardiology
- Biomarkers
- Heart Failure Research
Background:
- Acute heart failure (AHF) is a critical condition requiring accurate prognostic indicators.
- Identifying reliable biomarkers for predicting adverse outcomes in AHF patients is essential for timely intervention.
Purpose of the Study:
- To investigate the correlation between serum laminin (LN) levels and the prognosis of acute heart failure (AHF).
- To evaluate the predictive value of LN for major adverse cardiovascular events (MACE) in hospitalized AHF patients.
Main Methods:
- A cohort of 199 patients with AHF was studied.
- Serum LN levels were measured, and patients were categorized based on MACE occurrence during hospitalization.
- Receiver operating characteristic (ROC) curve analysis and multivariate logistic regression were employed.
Main Results:
- The area under the ROC curve for LN predicting MACE was 0.8144 (p < .0001), with a sensitivity of 88.37%.
- Increased LN levels were independently associated with MACE (OR: 1.020, 95% CI: 1.012-1.028).
- Decreased ejection fraction and diastolic blood pressure were also independent predictors of MACE.
Conclusions:
- Elevated serum LN levels are independently correlated with MACE in hospitalized AHF patients.
- Serum LN shows potential as a serological indicator for poor prognosis in AHF.
Objective:
To investigate the correlation between serum laminin (LN) level and the prognosis of acute heart failure (AHF).
Methods:
A total of 199 patients with AHF treated in Nantong First People's Hospital from March 2019 to November 2021 were included in this study. The patients were divided into the event group and the non-event group according to whether major adverse cardiovascular events (MACEs) occurred during hospitalization. We collected the baseline data of all patients and their LN levels were measured. The receiver operating characteristic (ROC) curve was used to analyze the predictive value of LN for the occurrence of MACE in AHF patients during hospitalization. Multivariate Logistic regression analysis was used to screen the independent factors associated with the occurrence of MACE in patients with AHF.
Results:
Among 199 patients with AHF, 43 were in the event group and 156 were in the non-event group. The area under ROC curve of LN to predict MACE in AHF patients during hospitalization was 0.8144, 95% confidence interval (CI): 0.7433-0.8855, p < .0001, cutoff point = 77.9, specificity 58.33%, and sensitivity 88.37%. Multivariate logistic regression analysis showed that the independent factors associated with the occurrence of MACE in AHF patients were the increase of LN level (odds ratio [OR]: 1.020, 95% CI: 1.012-1.028), the decrease of ejection fraction (OR: 0.007, 95% CI: 0.000-0.362) and diastolic blood pressure (OR: 0.946, 95% CI: 0.913-0.981; p < .05).
Conclusion:
The increase of LN level is independently correlated with the occurrence of MACE in AHF patients during hospitalization, which has the potential to be a serological indicator for poor prognosis in patients with AHF.
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