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Updated: Jun 13, 2026
09:53
In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
Published on: June 15, 2018
LncRNA HOXA11-AS Promotes Myocardial Injury in Chronic Heart Failure by Sponging miR-342-3p
Ying Zhang1, Ying Jiang1, Jiaqi Ye1
1Department of General Practice, Nantong First People's Hospital (Affiliated Hospital 2 of Nantong University), Nantong, China.
Summary
Long non-coding RNA HOXA11-AS is upregulated in chronic heart failure (CHF) patients and exacerbates myocardial injury by targeting miR-342-3p. HOXA11-AS shows diagnostic potential for CHF.
Area of Science:
- Cardiology
- Molecular Biology
- Biochemistry
Background:
- Chronic heart failure (CHF) is a complex condition with significant morbidity.
- Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in cardiovascular diseases.
- HOXA11-AS has been implicated in various biological processes, but its role in CHF remains unclear.
Purpose of the Study:
- To investigate the diagnostic value of lncRNA HOXA11-AS in chronic heart failure (CHF).
- To elucidate the underlying mechanism of HOXA11-AS in myocardial injury associated with CHF.
Main Methods:
- Serum HOXA11-AS levels were quantified using RT-qPCR in CHF patients.
- Diagnostic efficacy was assessed via ROC curve analysis.
- A doxorubicin-induced cell model of CHF was used to evaluate HOXA11-AS function.
- Cell viability, apoptosis, inflammatory factors, oxidative stress markers, and the HOXA11-AS/miR-342-3p interaction were analyzed.
Main Results:
- HOXA11-AS expression was significantly elevated in the serum of CHF patients.
- HOXA11-AS demonstrated high diagnostic accuracy for CHF.
- Knockdown of HOXA11-AS improved cell viability, reduced apoptosis, and mitigated myocardial injury, inflammation, and oxidative stress in vitro.
- HOXA11-AS directly targets miR-342-3p, and its inhibition reversed the protective effects.
Conclusions:
- HOXA11-AS serves as a potential diagnostic biomarker for CHF.
- HOXA11-AS exacerbates myocardial injury, inflammation, and oxidative stress in CHF by sponging miR-342-3p.
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