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Updated: Jul 28, 2025
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Platelet versus plasma CXCL14, coronary artery disease, and clinical outcomes
Christoph Schories1, Peter Martus2, Tianyun Guan1,3
1Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
Insights
Lower circulating CXCL14 levels in patients with coronary artery disease (CAD) indicate a worse prognosis. Platelet-associated CXCL14 levels differ between CAD patient groups and are associated with left ventricular ejection fraction (LVEF).
Area of Science:
- Cardiovascular Biology
- Immunology
- Biochemistry
Background:
- Platelets express CXCL14, a chemokine that influences monocyte behavior and angiogenesis.
- Platelet-derived CXCL14 plays a role in inflammatory and vascular processes.
Purpose of the Study:
- To investigate platelet surface-associated and circulating CXCL14 levels in heart disease patients.
- To determine the association of CXCL14 with myocardial function and outcomes in coronary artery disease (CAD).
Main Methods:
- Prospective study of 450 symptomatic heart disease patients.
- Analysis of platelet surface-associated and plasma CXCL14 levels.
- Follow-up for 360 days for major adverse cardiovascular events (MACE).
Main Results:
- Platelet-associated CXCL14 was lower in chronic coronary syndrome patients compared to acute coronary syndrome and non-CAD groups.
- Lower platelet CXCL14 and higher circulating CXCL14 were observed in patients with normal left ventricular ejection fraction (LVEF).
- Low circulating CXCL14, but not platelet CXCL14, predicted worse outcomes in CAD patients.
Conclusions:
- CXCL14 levels are differentially regulated on platelets and in circulation in CAD patients.
- Impaired LVEF is associated with increased platelet-associated CXCL14 and decreased circulating CXCL14.
- Circulating CXCL14 levels at admission are a significant prognostic marker for CAD patients.
Background:
Platelets express CXCL14, while platelet-derived CXCL14 induces monocyte chemotaxis and exerts an angiostatic effect on endothelial cells.
Objectives:
This study investigated both platelet surface-associated and circulating levels of CXCL14 in patients with heart disease and associations of this chemokine with myocardial function and outcomes in patients with coronary artery disease (CAD).
Methods:
This prospective study enrolled 450 patients with symptomatic heart disease. Platelet surface-associated and plasma CXCL14 levels were analyzed. All patients were followed up for 360 days for a primary composite outcome consisting of all-cause mortality, myocardial infarction, and/or ischemic stroke. Secondary outcomes consisted of the single events of all-cause mortality or myocardial infarction.
Results:
Baseline platelet-associated but not circulating CXCL14 levels were significantly lower in patients with chronic coronary syndrome (mean fluorescence intensity logarithmized, 1.35 ± 0.35) when compared to those with acute coronary syndrome (1.47 ± 0.38) and without CAD (1.51 ± 0.40). Platelet CXCL14 levels were significantly lower (1.37 ± 0.37 vs 1.48 ± 0.39) and circulating CXCL14 levels were significantly higher (lg, 2.88 ± 0.20 pg/mL vs 2.82 ± 0.26 pg/mL) in patients with normal baseline left ventricular ejection fraction (LVEF) when compared to those with impaired LVEF. Low baseline circulating CXCL14 (hazard ratio, 2.33; 1.00-5.46) but not platelet CXCL14 was associated with worse outcome in patients with CAD.
Conclusion:
Platelet-associated and circulating CXCL14 levels show differential regulation in patients with and without CAD. Although platelet-associated CXCL14 increased and circulating CXCL14 decreased with impairment of LVEF, only lower circulating CXCL14 upon admission was associated with worse prognosis in patients with CAD.
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