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Regenerative Endodontic Procedures in Teeth with Root Resorption: A Systematic Review.

Ashwini Manish Dadpe1, Dipali Yogesh Shah1, Velmurugan Natanasabapathy2

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Regenerative endodontic therapy (RET) shows promise in halting root resorption and resolving symptoms in most cases. However, the current evidence level is low-to-moderate, necessitating further high-quality clinical studies.

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Area of Science:

  • Dentistry
  • Endodontics
  • Regenerative Medicine

Background:

  • Root resorption is a pathological process affecting teeth.
  • Regenerative endodontic therapy (RET) aims to restore diş tissue vitality and function.
  • Limited clinical evidence exists for RET in managing root resorption.

Purpose of the Study:

  • To systematically review and critically evaluate clinical studies on regenerative endodontic therapy for root resorption.
  • To assess the efficacy and outcomes of RET in treating root resorption in permanent teeth.

Main Methods:

  • Systematic literature search of MEDLINE, Scopus, Cochrane, and Google Scholar (2001-2022).
  • Inclusion of case reports, case series, and clinical studies on RET for root resorption.
  • Appraisal of study quality using JBI Critical Appraisal Checklist and MINORS tool.

Main Results:

  • 14 studies (34 teeth) were included, showing RET arrested resorption and resolved symptoms in most cases.
  • Cone beam computed tomography (CBCT) in one study indicated significant lesion volume reduction post-RET.
  • Evidence quality was assessed as low-to-moderate, with varying study appraisal scores.

Conclusions:

  • Regenerative endodontic therapy demonstrates potential for managing root resorption.
  • Further well-designed, long-term clinical studies are required to establish RET as a standard treatment.
  • Current evidence suggests RET is a viable option, but requires more robust clinical validation.