Regenerative Endodontic Procedures in Teeth with Root Resorption: A Systematic Review.

Area of Science:

• Dentistry
• Endodontics
• Regenerative Medicine

Background:

• Root resorption is a pathological process affecting teeth.
• Regenerative endodontic therapy (RET) aims to restore diş tissue vitality and function.
• Limited clinical evidence exists for RET in managing root resorption.

Purpose of the Study:

• To systematically review and critically evaluate clinical studies on regenerative endodontic therapy for root resorption.
• To assess the efficacy and outcomes of RET in treating root resorption in permanent teeth.

Main Methods:

• Systematic literature search of MEDLINE, Scopus, Cochrane, and Google Scholar (2001-2022).
• Inclusion of case reports, case series, and clinical studies on RET for root resorption.
• Appraisal of study quality using JBI Critical Appraisal Checklist and MINORS tool.

Main Results:

• 14 studies (34 teeth) were included, showing RET arrested resorption and resolved symptoms in most cases.
• Cone beam computed tomography (CBCT) in one study indicated significant lesion volume reduction post-RET.
• Evidence quality was assessed as low-to-moderate, with varying study appraisal scores.

Conclusions:

• Regenerative endodontic therapy demonstrates potential for managing root resorption.
• Further well-designed, long-term clinical studies are required to establish RET as a standard treatment.
• Current evidence suggests RET is a viable option, but requires more robust clinical validation.