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Recent advances in lipid-based long-acting injectable depot formulations
Reena Sharma1, Sheetal Yadav1, Vivek Yadav1
1Department of Pharmaceutics, Centre for Pharmaceutical Nanotechnology, National Institute of Pharmaceutical Education & Research (NIPER), Sector 67, S.A.S. Nagar (Mohali), Punjab 160062, India.
Advanced Drug Delivery Reviews
|May 31, 2023
Summary
Long-acting injectable (LAI) systems using lipid depots offer sustained drug delivery, reducing dosage frequency and improving patient compliance for chronic diseases. This review highlights advancements, market availability, and challenges in developing these innovative lipid-based LAIs.
Area of Science:
- Pharmaceutical Sciences
- Biomaterials Engineering
- Drug Delivery Systems
Background:
- Long-acting injectables (LAIs) enhance therapeutic outcomes by providing sustained drug release.
- Lipid-based depots are biocompatible and improve drug stability for chronic disease management.
- Existing LAI formulations include oil solutions, liposomes, and lipid nanoparticles.
Purpose of the Study:
- To review recent advancements in lipid-based LAIs for small and macromolecules.
- To discuss the potential of lipid-based LAIs in managing chronic diseases.
- To provide an overview of available lipid depots, patents, and challenges in LAI development.
Main Methods:
- Comprehensive literature review of scientific databases and patent repositories.
- Analysis of lipid depot formulations, including oil solutions, oleogels, liposomes, and lipid nanoparticles.
- Critical discussion on in vitro release methods and in vitro-in vivo correlation (IVIVC).
Main Results:
- Lipid-based LAIs show significant promise for treating chronic conditions like psychosis, diabetes, and cancer.
- Various lipid depot types are available, with some in clinical phases and protected by patents.
- In vitro release studies are crucial but challenging for establishing reliable IVIVC.
Conclusions:
- Lipid-based LAIs represent a significant advancement in drug delivery for chronic diseases.
- Further research is needed to overcome challenges in developing and validating these systems.
- Successful development of lipid-based LAIs can improve patient compliance and therapeutic efficacy.
Keywords:
In vitro releaseLipid-based depotsLiposomesLiquid crystalline systemLong-acting injectablesOleogelsPhospholipid phase separation gelSustained releaseMore Related Videos
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