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Diagnosis of Chronic Kidney Disease and Assessing Glomerular Filtration Rate

Abinet M Aklilu1

  • 1Section of Nephrology, Department of Medicine, Yale school of Medicine, 60 Temple Street, Suite 6C, New Haven, CT 06510, USA.

The Medical Clinics of North America
|May 31, 2023
PubMed

Insights

Chronic kidney disease (CKD) diagnosis requires assessing kidney function and damage markers like albuminuria. Incorporating causes and social determinants of health improves CKD care plans and addresses disparities.

Area of Science:

  • Nephrology
  • Public Health

Background:

  • Chronic kidney disease (CKD) is a progressive condition often diagnosed late.
  • Current diagnosis relies on glomerular filtration rate (GFR) and albuminuria, but lacks comprehensive assessment.
  • CKD disparities are linked to social determinants of health.

Purpose of the Study:

  • To emphasize a comprehensive approach to CKD diagnosis.
  • To highlight the importance of identifying CKD causes and prognosis.
  • To underscore the role of social determinants in CKD disparities.

Main Methods:

  • Assessing glomerular filtration rate (GFR) using both serum creatinine and cystatin C.
  • Evaluating kidney damage markers, including albuminuria.
  • Investigating social determinants of health impacting CKD.

Main Results:

  • Combined serum cystatin C and creatinine provide a more accurate GFR estimation.
  • Comprehensive CKD diagnosis requires evaluating GFR, albuminuria, cause, trajectory, and prognosis.
  • Social determinants of health are critical factors contributing to CKD disparities.

Conclusions:

  • A thorough CKD diagnosis involves more than just GFR and albuminuria.
  • Integrating cause, trajectory, prognosis, and social determinants enhances CKD care.
  • Addressing social determinants is crucial for mitigating CKD disparities.

Keywords:
CKD diagnosisChronic kidney diseaseEstimating GFRGlomerular filtration rateKidney functionMeasuring GFRMonitoring GFR

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