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Ferrets as Models for Viral Respiratory Disease.

Rachel E Smith, Shambhunath Choudhary, Julita A Ramirez1

  • 1Pfizer Worldwide Research, Development & Medical, Pearl River, New York 10965, USA;,

Comparative Medicine
|May 31, 2023
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Summary

Domestic ferrets are valuable biomedical models for studying respiratory viruses like influenza and COVID-19. This review covers essential ferret biology and management for accurate and reproducible research.

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Area of Science:

  • Veterinary Medicine
  • Comparative Pathology
  • Animal Models

Background:

  • Domestic ferrets (Mustela putorius furo) have a long history in influenza research.
  • Their susceptibility and anatomical similarities to humans make them ideal for studying viral respiratory diseases.
  • This review focuses on considerations for using ferrets in respiratory disease models.

Approach:

  • Discusses key aspects of ferret biology and management relevant to research.
  • Covers biosafety, husbandry, clinical and pathological assessments, and anesthesia.
  • Reviews ferret respiratory anatomy and their use in studying influenza and COVID-19.

Key Points:

  • Proper management ensures animal welfare and model fidelity.
  • Anesthetic considerations are crucial for ferrets with respiratory or systemic illness.
  • Accurate data collection relies on understanding ferret-specific needs.

Conclusions:

  • Ferrets are critical animal models for understanding human respiratory viral infections.
  • Considerations for ferret biology and management enhance research reproducibility.
  • This review provides essential guidance for researchers working with ferrets.