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Published on: January 28, 2020
Plasma sLRP-1 Level Independently Relates to a Higher Risk of Moderate-Severe Stenosis by Gensini Score in Acute
Wei Qin1, Wenping Xue1, Jinxin Nie1
1Department of Cardiology, The Affiliated Hospital of Chengde Medical College.
Insights
Plasma levels of soluble low-density lipoprotein receptor-related protein-1 (sLRP-1) are elevated in acute coronary syndrome (ACS) patients. Increased sLRP-1 indicates greater coronary artery stenosis severity and poorer cardiac function in ACS.
Area of Science:
- Cardiovascular Medicine
- Biomarkers
- Atherosclerosis Research
Background:
- Soluble low-density lipoprotein receptor-related protein-1 (sLRP-1) is implicated in inflammation, lipid accumulation, and atherosclerosis, key factors in cardiovascular diseases.
- Understanding biomarkers that reflect disease severity in acute coronary syndrome (ACS) is crucial for patient management.
Purpose of the Study:
- To investigate the association between plasma sLRP-1 levels and the degree of coronary artery stenosis in ACS patients.
- To evaluate sLRP-1 as a potential biomarker for stenosis severity and cardiovascular risk in ACS.
Main Methods:
- Plasma sLRP-1 was measured using enzyme-linked immunosorbent assay in 169 ACS patients and 77 controls.
- Coronary artery stenosis severity was assessed using the Gensini score.
- Statistical analyses included correlation, regression, and assessment of diagnostic ability.
Main Results:
- ACS patients exhibited significantly higher plasma sLRP-1 levels compared to controls.
- Plasma sLRP-1 positively correlated with inflammatory markers (white blood cells, neutrophils) and cardiac injury markers (troponin I, BNP).
- sLRP-1 was independently associated with moderate-to-severe coronary artery stenosis and demonstrated a combined predictive value with ejection fraction and lesion number.
Conclusions:
- Elevated plasma sLRP-1 levels in ACS patients reflect increased inflammation, impaired cardiac function, and notably, higher coronary artery stenosis severity.
- sLRP-1 may serve as a valuable biomarker for assessing stenosis severity in ACS.
- A combination of sLRP-1, ejection fraction, and lesion count effectively predicts moderate-to-severe stenosis risk.
Abstract:
Soluble low-density lipoprotein receptor-related protein-1 (sLRP-1) plays a crucial role in facilitating inflammation, lipid accumulation, and atherosclerosis, and the latter factors are involved in the pathology of cardiovascular diseases. This study aimed to explore the ability of plasma sLRP-1 for reflecting stenosis degree in acute coronary syndrome (ACS) patients. sLRP-1 was detected from plasma by enzyme-linked immunosorbent assay in 169 ACS patients and 77 non-ACS subjects (as controls) after admission. Our study illustrated that sLRP-1 was increased in ACS patients versus controls (P < 0.001). Meanwhile, sLRP-1 was positively correlated with body mass index (P = 0.021), white blood cells (P = 0.009), neutrophils (P = 0.002), cardiac troponin I (P = 0.009), and brain natriuretic peptide (P = 0.008) in ACS patients. Notably, sLRP-1 was positively associated with the Gensini score (P = 0.002) and Gensini score stratified stenosis severity (P = 0.004) in ACS patients. After adjustment, sLRP-1 [odds ratio (OR) = 1.333, P = 0.045] independently estimated a higher risk of moderate-severe stenosis, so did numbers of coronary artery lesions (OR = 2.869, P = 0.001), but ejection fraction forecasted a lower risk (OR = 0.880, P = 0.012). Interestingly, a combination of sLRP-1, ejection fraction, and numbers of coronary artery lesions exhibited a good ability to estimate moderate-severe stenosis risk with an area under the curve (95% confidence interval) of 0.845 (0.783-0.906). In summary, increased plasma sLRP-1 represents an aggravated inflammation, impaired cardiac function, and especially a higher stenosis severity in ACS patients.
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