Related Experiment Video
Updated: Oct 17, 2026

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
Published on: July 7, 2016
[Comparative pharmacokinetic studies on the relative biologic availability of two propranolol preparations in
Abstract:
Plasma propranolol concentrations were analyzed after Obsidan (VEB Isis-Chemie, Zwickau, GDR) (= preparation A) and another propranolol-preparation (= preparation B) in 10 patients with arterial hypertension of clinical stage I-II in a cross-over design. The concentration-time-curves (AUC0----infinity) were investigated up to 24 h after the oral intake of 40 mg of both preparations of propranolol and were nearly identical. In comparison with preparation B the relative bioavailability F was 104% for preparation A. The steady-state plasma concentrations of propranolol were within the therapeutic range of 50-100 ng/ml. They showed only interindividual variations about the factor 2-3. Peak plasma concentrations were observed 1,5-2 h after the oral application. There were no statistical differences in the pharmacokinetic parameters between the both preparations. The rate of elimination constants of 0,065 to 0,073 h-1 after preparation A and B explain the long duration of the therapeutic efficacy during chronic treatment.
Related Concept Videos
Bioequivalence: Overview
Antihypertensive Drugs: Types of β-Blockers
Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This relationship...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Measurement of Bioavailability: Pharmacodynamic Methods
Bioequivalence studies: Biowaivers