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Antigens Involved in Adaptive Immunity

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
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Updated: Jul 28, 2025

Antigenic Liposomes for Generation of Disease-specific Antibodies

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Computational Vaccine Design for Common Allergens.

Nandini Ghosh¹, Gaurab Sircar², Sudipto Saha³

¹Department of Microbiology, Vidyasagar University, Midnapore, West Bengal, India.

Methods in Molecular Biology (Clifton, N.J.)

|May 31, 2023

Summary

This summary is machine-generated.

This chapter details designing allergen-specific immunotherapy (AIT) vaccine molecules using immunoinformatics. Modern AIT approaches focus on carrier-bound B cell epitopes and multi-epitope designs, with strategies and tools discussed.

Keywords:

Allergen-specific immunotherapy Carrier-bound B cell epitope Hypoallergenic Multi-epitope Non-anaphylactic peptide Vaccine

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Published on: April 21, 2019

Area of Science:

Immunology
Bioinformatics
Vaccine Design

Background:

Allergen-specific immunotherapy (AIT) aims to desensitize patients to allergens.
Traditional AIT methods face challenges in efficacy and safety.
Modern AIT strategies involve designing targeted vaccine molecules.

Purpose of the Study:

To outline the process of designing novel vaccine molecules for AIT.
To explain the application of immunoinformatics in vaccine development.
To detail modern AIT approaches using B cell epitopes and multi-epitope designs.

Main Methods:

Utilizing immunoinformatics for the identification and design of B cell epitopes.
Employing bioinformatics tools and servers for in silico vaccine molecule construction.
Developing strategies for carrier-bound and multi-epitope vaccine designs.

Main Results:

A systematic approach for designing candidate AIT vaccine molecules is presented.
The chapter provides a comprehensive overview of relevant bioinformatics tools and servers.
The described methodology facilitates the creation of advanced AIT vaccine candidates.

Conclusions:

Immunoinformatics offers a powerful platform for designing next-generation AIT vaccines.
Carrier-bound B cell epitopes and multi-epitope designs represent a modern frontier in AIT.
This chapter serves as a guide for researchers developing novel immunotherapies for allergies.