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Dysregulation of Transfer RNA-derived Small RNAs that Regulate Cell Activity and its Related Signaling Pathways in

Tianyi Huang1, Juan Du1, Chujia Chen1

  • 1Health Science Center, Ningbo University, Ningbo, 315211, Zhejiang, China.

Current Gene Therapy
|June 1, 2023
PubMed

Insights

Small tRNA-derived RNAs (tsRNAs) regulate gene expression and cellular activities. Their dysregulation in cancer impacts cell proliferation, apoptosis, and migration, often by influencing key signaling pathways.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Small noncoding RNAs, known as tsRNAs, are derived from tRNA cleavage.
  • tsRNAs regulate crucial cellular processes including gene expression, translation, and epigenetic modification.
  • Dysregulated tsRNAs are implicated in cancer, affecting cell proliferation, apoptosis, migration, and invasion.

Conclusions:

  • tsRNAs are critical regulators in both normal cellular functions and cancer development.
  • Understanding tsRNA mechanisms in signaling pathways offers therapeutic potential.
  • Further research into tsRNAs is essential for cancer treatment strategies.
Keywords:
cancercell activitydysregulationsignaling pathwaytRFstsRNAs

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