Related Experiment Video
Updated: Jul 28, 2025
Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
Published on: July 5, 2019
A Molecular Blueprint to Targeting ALK Gene Fusions in Glioblastoma
Stephen C Mack1,2, Kelsey C Bertrand2,3
1Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Abstract:
Glioblastoma (GBM) is a heterogeneous brain tumor entity from infancy through adulthood. ALK gene fusions enriched in congenital and infant GBM have emerged as druggable driver alterations. Understanding the molecular basis and prevalence of ALK gene rearrangements will help define patients with GBM who may benefit from ALK-targeted therapy. See related article by Blandin et al., p. 2651.
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