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Updated: Jul 28, 2025

Tracking and Quantifying Developmental Processes in C. elegans Using Open-source Tools
Published on: December 16, 2015
Developmental mechanisms understood quantitatively
Veronica Biga1, Tom P J Wyatt2, Diana Pinheiro3
1Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PT, UK.
Abstract:
Across developmental systems, quantitative and imaging-based approaches have provided unprecedented resolution of dynamic changes in gene regulation and cell fate specification, along with complex changes in tissue morphology. This has set the stage for a wealth of comprehensive theoretical models, parameterised by experimental data, able to reproduce key aspects of biological behaviour and jointly enabling a higher level of abstraction, going from the identification of the molecular components to understanding complex functional relationships between these components. Despite these successes, gaining a cross-scale understanding of developmental systems will require further collaboration between disciplines, from developmental biology to bioengineering, systems biology and biophysics. We highlight the exciting multi-disciplinary research discussed at The Company of Biologists workshop 'Fostering quantitative modelling and experimentation in Developmental Biology'.
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