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Methods to Improve the Stability of Nucleic Acid-Based Nanomaterials
Xueping Xie1, Wenjuan Ma2, Yuxi Zhan2
1Department of Stomatology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, P.R. China.
Current Drug Metabolism
|June 2, 2023
Summary
Nucleic acid-based nanomaterials (NANs) show promise in biomedicine but face stability issues. This review explores methods to enhance NAN stability for broader applications.
Area of Science:
- Biotechnology and Nanotechnology
- Materials Science
- Biomedical Engineering
Background:
- Nucleic acid-based nanomaterials (NANs) are programmable, biocompatible, and non-immunogenic materials synthesized via base pairing.
- NANs have significant potential in biomedical applications like drug delivery and biosensing.
- The practical application of NANs is limited by their susceptibility to degradation.
Approach:
- This review summarizes current strategies to improve the stability of nucleic acid-based nanomaterials.
- Methods discussed include the use of artificial nucleic acids and specific chemical modifications.
- Encapsulation techniques using protective structures are also examined.
Key Points:
- NANs can degrade due to low cation concentrations, enzymatic activity, and organic solvents.
- Stability is a critical factor hindering the widespread use of NANs in biomedical fields.
- Various approaches are being developed to overcome these stability limitations.
Conclusions:
- Enhancing the stability of NANs is crucial for unlocking their full potential in drug delivery and diagnostics.
- Continued research into stabilization methods will facilitate the translation of NANs from laboratory to clinical applications.
- Understanding degradation pathways is key to designing more robust nucleic acid-based nanomaterials.
