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3D-Printed Piezoelectric Scaffolds with Shape Memory Polymer for Bone Regeneration
Guanlin Li1, Zehao Li1, Yajun Min1
1State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, 430070, China.
Small (Weinheim an Der Bergstrasse, Germany)
|June 2, 2023
Summary
Novel 3D-printed piezoelectric scaffolds using acrylate epoxidized soybean oil (AESO) and Ag-TMSPM-pBT (ATP) nanoparticles show enhanced piezoelectric properties. These AESO-ATP scaffolds promote bone regeneration in vitro and in vivo, offering potential for bone defect repair.
Area of Science:
- Biomaterials Engineering
- Regenerative Medicine
- Nanotechnology
Background:
- Piezoelectric nanoparticles integrated with shape memory polymers (SMPs) offer potential for 3D-printed scaffolds in bone defect repair.
- A significant dielectric constant mismatch between piezoelectric and polymer phases limits scaffold piezoelectric properties.
- Developing advanced piezoelectric scaffolds requires overcoming limitations in material compatibility and performance.
Purpose of the Study:
- To develop novel 3D-printed piezoelectric scaffolds with enhanced properties for bone regeneration.
- To investigate the effect of Ag-TMSPM-pBT (ATP) nanoparticles on acrylate epoxidized soybean oil (AESO) scaffolds.
- To evaluate the piezoelectric, shape memory, and osteogenic capabilities of the developed scaffolds.
Main Methods:
- Digital light processing 3D-printing was used to fabricate AESO scaffolds doped with Ag-TMSPM-pBT (ATP) nanoparticles.
- TMSPM covalent functionalization and conductive Ag nanoparticles were employed to enhance ATP nanoparticle piezoelectricity.
- Piezoelectric coefficient (d33), output current, shape memory recovery under near-infrared (NIR) light, and osteogenic differentiation of BMSCs were evaluated.
Main Results:
- AESO scaffolds doped with 10 wt% ATP nanoparticles (AESO-10ATP) exhibited improved piezoelectric properties (d33 = 0.9 pC N⁻¹, output current = 146.4 nA).
- The AESO-10ATP scaffolds demonstrated effective shape memory recovery upon NIR light irradiation.
- In vitro and in vivo studies showed that AESO-10ATP scaffolds promote osteogenic differentiation and bone defect repair.
Conclusions:
- The 3D-printed AESO-ATP piezoelectric scaffolds possess excellent piezoelectric and shape memory properties.
- These scaffolds effectively promote osteogenic differentiation and bone regeneration.
- AESO-10ATP piezoelectric scaffolds show significant potential for clinical applications in bone defect repair.
