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Pancreatic Neoplasms Are Frighteningly Common: A Role for Immune Surveillance?
Megan T Hoffman1,2, Stephanie K Dougan1,2
1Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Cancer Discovery
|June 2, 2023
Abstract
Summary:
Carpenter and colleagues analyze organ donors to find that pancreatic intraepithelial neoplasia (PanIN), the precursor lesions of pancreatic ductal adenocarcinoma, are highly prevalent in the average healthy adult starting from a young age. Why these precursor lesions do not progress to cancer in most people is a mystery. See related article by Carpenter et al., p. 1324 (1).

