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Updated: Jul 28, 2025

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Visible-Light-Promoted Radical Cross-Dehydrogenative Coupling of C(sp3)-H/C(sp3)-H and C(sp3)-H/C(sp2)-H via
Xinpeng Xie1, Kaikai Qiao1, Bing-Ru Shao1
1State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, P.R. China.
Abstract:
Cross-dehydrogenative coupling has emerged as a robust tool to construct C-C and C-heteroatom bonds. Herein, we reported an interesting visible-light-mediated radical CDC of C(sp3)-H/C(sp3)-H and C(sp3)-H/C(sp2)-H, enabled by a phenyl radical guided intermolecular HAT process. This strategy allowed the efficient coupling of a wide range of inert C(sp3)-H and C(sp2)-H with α-N C(sp3)-H of amines in good regioselectivities and yields. Mechanistic studies indicate that the EDA complex triggered an intermolecular HAT process.
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