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Related Experiment Video

Updated: Jul 28, 2025

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Thermo-induced physically crosslinked polypeptide-based block copolymer hydrogels for biomedical applications.

Dan Zhao^1,2, Yan Rong¹, Dong Li^1,2

¹CAS Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.

Regenerative Biomaterials

|June 2, 2023

Summary

This summary is machine-generated.

Injectable polypeptide hydrogels exhibit thermo-induced sol-gel transitions for biomedical uses. These biocompatible and biodegradable materials are promising for tissue regeneration and drug delivery.

Keywords:

immunotherapy injectable hydrogels polypeptides secondary conformation stimuli responsive tissue engineering

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Last Updated: Jul 28, 2025

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Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

Area of Science:

Materials Science
Biomedical Engineering
Polymer Chemistry

Background:

Stimuli-responsive synthetic polypeptide block copolymers are gaining attention.
Thermo-induced sol-gel transitions are observed in amphiphilic diblock copolypeptides and poly(ethylene glycol)-polypeptide block copolymers.

Purpose of the Study:

To review recent advances in injectable, thermo-induced, physically crosslinked polypeptide hydrogels.
To discuss the influence of polypeptide composition, secondary structure, and chirality on hydrogel properties and applications.
To highlight biomedical applications and future challenges.

Main Methods:

Investigation of physical parameters like polymer concentration, transition temperatures, and storage moduli.
Assessment of in vitro and in vivo biocompatibility and biodegradation.
Focus on design and preparation of thermo-responsive hydrogels.

Main Results:

Polypeptide hydrogels show unique thermo-induced sol-gel phase transitions.
Gelation mechanisms involve secondary conformation changes, intramolecular interactions, reduced hydration, and chain entanglement.
Hydrogels exhibit good biocompatibility and biodegradation within 1-5 weeks.

Conclusions:

Thermo-induced polypeptide hydrogels are suitable for minimally invasive injection and in situ formation.
They are promising for 3D cell culture, tissue regeneration, and drug delivery depots.
Further development is needed to address practical application challenges.