Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

184
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
184
Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

41
Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory...
41

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Research Progress on the Anti-Inflammatory and Antioxidant Effects of Daidzein: Its Mechanisms of Action in Related Diseases, and Related Nanoformulations to Enhance Its Bioavailability.

Antioxidants (Basel, Switzerland)·2026
Same author

Extraction, Purification, Structural Characterization, Biological Activities and Applications in Food of Polysaccharides from <i>Physalis alkekengi</i> L. Var. Franchetii (Mast.) Makino.

Foods (Basel, Switzerland)·2026
Same author

Measuring and optimizing spatial accessibility to emergency medical services with a focus on age-based spatial variations in EMS risk.

Frontiers in public health·2026
Same author

Bioorthogonal chemistry-driven multi-enzyme strategy for efficient terpenoid biosynthesis.

Bioresource technology·2026
Same author

Fatigue resistant cellulose aerogels with flame retardancy and hydrophobicity through a cross-scale reinforcement strategy.

International journal of biological macromolecules·2026
Same author

Case report: first-line lorlatinib in metastatic lung adenocarcinoma with a novel WIPF1-ALK and EML4-ALK dual fusion.

Translational lung cancer research·2026

Related Experiment Video

Updated: May 6, 2026

Creation and Transplantation of an Adipose-derived Stem Cell ASC Sheet in a Diabetic Wound-healing Model
08:06

Creation and Transplantation of an Adipose-derived Stem Cell ASC Sheet in a Diabetic Wound-healing Model

Published on: August 4, 2017

11.4K

Stimulus-responsive hydrogels for diabetic wound management via microenvironment modulation.

Yang Gao1, Xinxin Chen1, Chaoliang He2

  • 1Department of Burn Surgery, First Hospital of Jilin University, Changchun 130021, P.R. China. yuja@jlu.edu.cn.

Biomaterials Science
|May 12, 2025
PubMed
Summary
This summary is machine-generated.

Stimulus-responsive hydrogel dressings offer advanced strategies for treating diabetic wounds. These smart materials precisely modulate the wound microenvironment to accelerate healing by addressing infection, inflammation, and oxidative stress.

More Related Videos

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes
05:18

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

3.7K
Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
04:09

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

2.8K

Related Experiment Videos

Last Updated: May 6, 2026

Creation and Transplantation of an Adipose-derived Stem Cell ASC Sheet in a Diabetic Wound-healing Model
08:06

Creation and Transplantation of an Adipose-derived Stem Cell ASC Sheet in a Diabetic Wound-healing Model

Published on: August 4, 2017

11.4K
A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes
05:18

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

3.7K
Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
04:09

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

2.8K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Healing Research

Background:

  • Diabetic wounds are a significant clinical challenge due to complex pathophysiological characteristics.
  • Key issues include recurring bacterial infection, persistent inflammation, oxidative stress, and impaired angiogenesis.
  • Current treatments require comprehensive interventions tailored to these specific challenges.

Purpose of the Study:

  • To review the disease characteristics of chronic diabetic wounds.
  • To introduce current clinical treatment approaches.
  • To summarize the applications of stimulus-responsive hydrogels in diabetic wound treatment.

Main Methods:

  • Overview of diabetic wound pathophysiology.
  • Review of existing clinical treatment strategies.
  • Summary of cutting-edge hydrogel dressing applications.

Main Results:

  • Stimulus-responsive hydrogels offer novel therapeutic strategies for diabetic wounds.
  • These smart hydrogels can monitor and modulate the wound microenvironment in real-time.
  • Applications focus on addressing infection, inflammation, oxidative stress, and angiogenesis.

Conclusions:

  • Stimulus-responsive hydrogels represent a promising advancement in diabetic wound care.
  • Their ability to adapt to wound signals allows for precise therapeutic modulation.
  • These smart dressings accelerate healing by optimizing the wound microenvironment.