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Updated: Jul 28, 2025

A Small Animal Model of Ex Vivo Normothermic Liver Perfusion
Published on: June 27, 2018
Assessment of a Perfusion and Ventilation Method for Detecting Lung and Liver Injury in a Cadaveric Model
Cynthia Bir1, Monica Wong2, Rodrigo Villalta2
1Department of Biomedical Engineering, Wayne State University, 818 W. Hancock, Detroit, MI, 48201, USA. cbir@wayne.edu.
Abstract:
Surgical simulation models have been developed using post-mortem human subjects (PMHS). These models involve the pressurization and ventilation of the PMHS to create a more realistic environment for training and the practice of surgical procedures. The overall objective of this study was to determine the feasibility of a previously developed surgical simulation model to detect soft tissue injuries during a ballistic impact to the torso. One of the main limitations of using PMHS for the assessment of soft tissue injuries in the field of injury biomechanics is the lack of physiological blood flow. To overcome this limitation, the assessment of the surgical simulation model for use in injury biomechanics applications was conducted based on data collected from behind armor blunt trauma (BABT) case studies. Documented injuries in real-world cases included anterior lung contusion, posterior lung contusion, and liver contusion. These real-world injuries were compared to those seen post-impact in the PMHS using pathological and histological techniques. Discussion of limitations and future work is presented.

