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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.3K

New mechanisms involved in the development of cardiovascular disease in chronic kidney disease

Andrea Figuer1, Matilde Alique1, Gemma Valera1

  • 1Departamento de Biología de Sistemas, Universidad de Alcalá (IRYCIS), Alcalá de Henares (Madrid), Spain.

Nefrologia
|June 2, 2023
PubMed

Insights

Extracellular vesicles (EVs) contribute to cardiovascular disease (CVD) in chronic kidney disease (CKD) patients by causing endothelial damage. Targeting EVs may offer new diagnostic and therapeutic strategies for CKD-associated CVD.

Area of Science:

  • Nephrology
  • Cardiology
  • Biomedical Sciences

Background:

  • Chronic kidney disease (CKD) affects the elderly, often requiring renal replacement therapy.
  • CKD patients experience increased oxidative stress, inflammation, and extracellular vesicle (EV) release, contributing to cardiovascular disease (CVD).
  • EVs in CKD patients are elevated in plasma and altered in content, promoting endothelial dysfunction, senescence, and vascular calcification.

Purpose of the Study:

  • To review classic and novel mechanisms of CVD development in CKD.
  • To emphasize the critical role of EVs in CKD-associated cardiovascular pathologies.
  • To explore the potential of EVs as diagnostic and therapeutic tools in CKD.

Main Methods:

  • Literature review focusing on mechanisms of CVD in CKD.
  • Emphasis on the role of extracellular vesicles (EVs) and their components (e.g., miRNAs).
  • Analysis of EV involvement in endothelial dysfunction, vascular calcification, and thrombosis.

Main Results:

  • EVs from CKD patients induce endothelial dysfunction, senescence, and vascular calcification.
  • Altered EV content, including miRNAs, exacerbates endothelial dysfunction and thrombotic risks.
  • EVs are implicated as key mediators in the premature development of CVD in CKD.

Conclusions:

  • Extracellular vesicles play a significant role in the pathogenesis of cardiovascular disease in chronic kidney disease.
  • Modulating EV release or content presents a promising avenue for diagnosing and treating CKD-associated CVD.
  • Further research into EVs could lead to novel therapeutic strategies to mitigate cardiovascular risks in CKD patients.

Keywords:
Calcificación vascularCardiovascular diseaseChronic kidney diseaseDisfunción endotelialEndothelial dysfunctionEnfermedad cardiovascularEnfermedad renal crónicaExtracellular vesiclesMicrovesiclesMicrovesículasVascular calcificationVesículas extracelulares

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