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The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...

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Related Experiment Video

Updated: Jul 28, 2025

Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans

Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans

Published on: June 2, 2023

Human thermogenic adipose tissue.

Denis P Blondin¹

¹Division of Neurology, Department of Medicine, Centre de recherche du Centre hospitalier universitaire de Sherbrooke, Université de Sherbrooke, 3001, 12th Ave North, Sherbrooke, Quebec J1H 5N4, Canada.

Current Opinion in Genetics & Development

|June 3, 2023

Summary

This summary is machine-generated.

Human thermogenic adipose tissue offers therapeutic potential for obesity. Research explores its metabolism, function as an endocrine organ, and role as a biomarker for adipose tissue health, though measurement reliability is questioned.

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Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice

Published on: February 3, 2023

Area of Science:

Metabolic research
Adipose tissue biology
Obesity therapeutics

Background:

Human thermogenic adipose tissue is a key target for obesity and metabolic disease treatment.
Understanding in vivo human thermogenic adipose tissue metabolism is crucial.

Purpose of the Study:

To provide an overview of current knowledge on human thermogenic adipose tissue metabolism.
To explore the association between brown adipose tissue ([18F]fluorodeoxyglucose) accumulation and cardiometabolic risk factors.
To discuss the multifaceted roles of human brown adipose tissue.

Main Methods:

Review of retrospective and prospective studies.
Analysis of [18F]fluorodeoxyglucose accumulation in brown adipose tissue.
Evaluation of evidence for brown adipose tissue function.

Main Results:

Studies link brown adipose tissue ([18F]fluorodeoxyglucose) accumulation to cardiometabolic risk factors.
The reliability of [18F]fluorodeoxyglucose accumulation as an indicator of thermogenic capacity is questioned.
Evidence supports brown adipose tissue's roles as a thermogenic organ, endocrine organ, and biomarker.

Conclusions:

Human thermogenic adipose tissue holds significant therapeutic promise.
Brown adipose tissue functions locally and systemically, impacting metabolic health.
Further research is needed to clarify brown adipose tissue's precise role and measurement accuracy.