Related Experiment Video
Updated: Jul 28, 2025

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
Impact of crystalline structure on the digestibility of amylopectin-based starch-lipid complexes
Ren Wang1, Zhishu He1, Yijun Cao1
1Key Laboratory of Carbohydrate Chemistry and Biotechnology, National Engineering Research Center of Cereal Fermentation and Food Biomanufacturing, Jiangsu Provincial Research Centre for Bioactive Product Processing Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of China.
Abstract:
In this study, chain-elongated waxy corn starch (mWCS) was complexed with lauric acid (LA) to produce starch-lipid complexes (mWCS@LA) with a mixture of B- and V-type crystalline structures. Results from in vitro digestion showed that mWCS@LA had higher digestibility than mWCS, and the logarithm of slope plots of mWCS@LA revealed a two-stage digestion pattern, with digestion rate of the first stage (k1 = 0.038 min-1) being much higher than that of the following stage (k2 = 0.0116 min-1). The complexation between the long branch chains of mWCS and LA formed amylopectin-based V-type crystallites that were rapidly hydrolyzed during the first stage. The digesta isolated from the second stage of digestion had a B-type crystallinity of 52.6 %, and starch chains with degree of polymerization of 24-28 mainly contributed to the formation of the B-type crystalline structure. The results from the present study reveal that the B-type crystallites were more resistant to amylolytic hydrolysis than the amylopectin-based V-type crystallites.
More Related Videos
Related Concept Videos
Polymer Classification: Crystallinity
Crystalline domains are the regions where polymer chains are aligned in an orderly manner and held together in proximity by intermolecular forces. For example, chains in the crystalline domains of polyethylene and nylon are bound together by van der Waals...
Carbohydrate Digestion
Lipid Digestion
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
Chemistry of Carbohydrates

