[Comparative study of 2',3'-O-isopropylidene adenosine and adenosine transformation in rat liver homogenates]

Transformation of synthesized 2',3'-O-isopropylidene adenosine was studied in comparison with adenosine in rat liver homogenates. It is stated that 2',3'-O-isopropylidene adenosine is subjected to deamination similar to adenosine but less intensively. Due to deamination 2',3'-O-isopropylidene inosine is formed from 2',3'-O-isopropylidene adenosine. It is shown that under conditions of the conducted experiments enzymic splitting of the isopropylidene grouping from the preparation does not occur; this substrate contrary to adenosine does not split under the effect of purine nucleoside phosphorylase.