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Published on: January 7, 2019
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New prebiotics by ketone donation
1Department of Antiaging Food Research, School of Bioscience and Biotechnology, Tokyo University of Technology, 1404-1 Katakura, Hachioji 192-0982, Japan.
Trends in Endocrinology and Metabolism: TEM
|June 4, 2023
Summary
This study proposes using ketone donors, like poly-hydroxybutyrate (PHB), as prebiotics to improve gut health. Supplementing with 3-hydroxybutyrate (3HB) can enhance microbiome integrity and overall gut function.
Area of Science:
- Microbiology
- Gastroenterology
- Metabolic Health
Background:
- Gut microbiome integrity is crucial for human health.
- 3-Hydroxybutyrate (3HB), a ketone, regulates gut physiology and stem cell expansion.
- Current prebiotics may not fully optimize the gut environment.
Purpose of the Study:
- To propose novel prebiotics based on ketone (3HB) donation for enhanced gut health.
- To explore the potential of exogenous 3HB in modulating the gut microbiome and metabolic status.
- To investigate poly-hydroxybutyrate (PHB) as an effective prebiotic for gut health.
Main Methods:
- This is an opinion piece, proposing a novel approach.
- The proposed method involves supplying exogenous 3-hydroxybutyrate (3HB) via ketone donors.
- Focus on the influence of 3HB on gut microbiota and systemic metabolism.
Main Results:
- Exogenous 3HB donation has the potential to significantly improve gut health.
- 3HB can alter the gut microbiome composition and function.
- Poly-hydroxybutyrate (PHB) acts as a 3HB donor, influencing microbiota and improving the gut environment.
Conclusions:
- Exogenous 3HB donation represents a promising strategy for enhancing gut health.
- Utilizing ketone donors like PHB can maintain microbiome integrity.
- This approach offers a novel avenue for prebiotic development and gut health improvement.
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