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[Correlation between 25-hydroxyvitamin D and nephroblastoma in children and its value in assessing disease prognosis]

Li Zhao1, Xu-Kai Ma1, Yu Liu1

  • 1Department of Pediatrics, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|June 5, 2023
PubMed

Insights

Children with nephroblastoma have lower 25-hydroxyvitamin D [25-(OH)D] levels, which are linked to poorer outcomes. This vitamin D metabolite shows potential for predicting the prognosis of pediatric nephroblastoma.

Area of Science:

  • Pediatric Oncology
  • Endocrinology
  • Biochemistry

Context:

  • Nephroblastoma, a common pediatric kidney cancer, presents diagnostic and prognostic challenges.
  • Vitamin D deficiency is increasingly recognized as a factor in various diseases, including cancers.

Purpose:

  • To investigate the association between 25-hydroxyvitamin D [25-(OH)D] levels and the prognosis of nephroblastoma in children.
  • To evaluate the utility of 25-(OH)D as a predictive biomarker for pediatric nephroblastoma outcomes.

Summary:

  • Children with nephroblastoma exhibited significantly lower serum creatinine and 25-(OH)D levels compared to healthy controls.
  • Poor prognosis in nephroblastoma was associated with larger tumor size, advanced stage, metastasis, and lower 25-(OH)D levels.
  • Serum 25-(OH)D levels demonstrated a significant negative correlation with therapeutic response and were identified as a risk factor for poor prognosis.

Impact:

  • Findings suggest that 25-(OH)D levels can serve as a valuable tool for predicting nephroblastoma prognosis in children.
  • This research highlights the potential role of vitamin D status in pediatric cancer outcomes and warrants further investigation.
Abstract

Keywords:
25-Hydroxyvitamin DChildNephroblastomaPrognostic value

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