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Potential for cardiac toxicity with methylimidazolium ionic liquids

Tarek M Abdelghany1, Shireen A Hedya2, Carol De Santis3

  • 1Institute Translational and Clinical Research, Level 4 Leech, Newcastle University, Newcastle Upon Tyne NE2 4HH, United Kingdom; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo 11562, Egypt; School of Biomedical, Nutritional and Sport Sciences, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne NE24HH, United Kingdom.

Ecotoxicology and Environmental Safety
|June 5, 2023
PubMed
Summary

Methylimidazolium ionic liquids (MILs) can cause heart toxicity in rats, with longer chains being more harmful. Mice show less sensitivity due to higher cardiac BCRP expression, suggesting potential future human health risks.

Keywords:
AR42J-B13C8[mim]HeartIonic liquidsMTTTransporter

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