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Updated: Jul 28, 2025
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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
Published on: December 12, 2019
7.7K
Notch directs telencephalic development and controls neocortical neuron fate determination by regulating microRNA
Jisoo S Han1, Elizabeth Fishman-Williams1, Steven C Decker1
1Department of Cell Biology and Human Anatomy, University of California Davis, Davis, CA 95616, USA.
Development (Cambridge, England)
|June 5, 2023
Summary
Notch signaling is vital for brain development, controlling how neural stem cells become specific neuron types. This study reveals Notch
Area of Science:
- Neuroscience
- Developmental Biology
- Cell Biology
Background:
- The central nervous system arises from multipotent neural progenitors.
- Progenitor cell identity is influenced by spatial and temporal cues.
- Notch signaling is implicated in neural progenitor fate decisions, but mechanisms are unclear.
Purpose of the Study:
- To elucidate the role of Notch signaling in telencephalic development.
- To investigate how Notch signaling regulates neocortical progenitor behavior and neuron fate.
- To identify molecular targets of Notch signaling in the developing neocortex.
Main Methods:
- Investigated Notch signaling in mouse models.
- Analyzed neocortical and hippocampal morphogenesis.
- Examined the regulation of microRNA clusters by Notch signaling.
Main Results:
- Notch signaling is essential for neocortical and hippocampal morphogenesis, and development of the corpus callosum and choroid plexus.
- Notch signaling regulates projection neuron fate in the neocortex.
- Notch controls specific microRNA clusters, including let-7, miR-99a/100, and miR-125b.
Conclusions:
- Balanced Notch signaling is critical for overall telencephalic development.
- The interplay between Notch signaling and microRNAs is essential for neocortical progenitor behavior and neuron fate determination.
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