Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

1.8K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.8K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

1.1K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
1.1K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

663
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
663
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

910
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
910
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

1.0K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.0K
Humoral Immune Responses01:36

Humoral Immune Responses

73.3K
Overview
73.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deleterious germline CARD11 gain-of-function variants alter human B-cell and CD4+ T-cell differentiation and function.

Clinical and experimental immunology·2026
Same author

Human CD21<sup>lo</sup>T-bet<sup>+</sup> B cells: Not as easy as "ABC"!

Journal of human immunity·2026
Same author

CSF1R-dependent CD169-positive macrophages locally constrain melanoma growth in the skin.

The Journal of experimental medicine·2026
Same author

Functional immune profiling reveals CD4<sup>+</sup> T cell dysregulation in coeliac disease.

Immunology and cell biology·2026
Same author

The 2024 update of IUIS phenotypic classification of human inborn errors of immunity.

Journal of human immunity·2026
Same author

Human inborn errors of immunity: 2024 update on the classification from the International Union of Immunological Societies Expert Committee.

Journal of human immunity·2026
Same journal

Retraction: In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation.

The Journal of experimental medicine·2026
Same journal

Intravesical mesothelin-based CAR T cells targeting MUC16 effectively control bladder cancer in preclinical models.

The Journal of experimental medicine·2026
Same journal

Flawed translation triggers oncogenic B-T cell communication.

The Journal of experimental medicine·2026
Same journal

Correction: LCK'ed in: Inborn errors of immunity in LCK reveal how TCR signaling is calibrated.

The Journal of experimental medicine·2026
Same journal

Mechanobiology of inflammation: Pulling the strings of innate immunity.

The Journal of experimental medicine·2026
Same journal

Bile acid retention in efferocytic macrophages shapes their inflammatory status during cholangitis.

The Journal of experimental medicine·2026
See all related articles

Related Experiment Video

Updated: Jul 28, 2025

Flow Cytometric Characterization of Murine B Cell Development
08:25

Flow Cytometric Characterization of Murine B Cell Development

Published on: January 22, 2021

16.0K

Inborn errors of human B cell development, differentiation, and function.

Stuart G Tangye1,2, Tina Nguyen1,2, Elissa K Deenick1,2

  • 1Garvan Institute of Medical Research , Darlinghurst, Australia.

The Journal of Experimental Medicine
|June 5, 2023
PubMed
Summary
This summary is machine-generated.

Inborn errors reveal how B cells produce antibodies, crucial for long-term immunity and vaccine success. Studying these genetic defects illuminates human humoral immunity and B cell development pathways.

More Related Videos

Isolation of Precursor B-cell Subsets from Umbilical Cord Blood
14:06

Isolation of Precursor B-cell Subsets from Umbilical Cord Blood

Published on: April 16, 2013

18.1K
Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
09:35

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

Published on: April 20, 2021

6.8K

Related Experiment Videos

Last Updated: Jul 28, 2025

Flow Cytometric Characterization of Murine B Cell Development
08:25

Flow Cytometric Characterization of Murine B Cell Development

Published on: January 22, 2021

16.0K
Isolation of Precursor B-cell Subsets from Umbilical Cord Blood
14:06

Isolation of Precursor B-cell Subsets from Umbilical Cord Blood

Published on: April 16, 2013

18.1K
Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
09:35

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

Published on: April 20, 2021

6.8K

Area of Science:

  • Immunology
  • Genetics

Background:

  • B cells are vital for host defense, producing antibodies (Ab) to clear pathogens.
  • Memory B cells and plasma cells (PCs) ensure long-lived humoral immunity and protection against recurrent infections.
  • Effective vaccines rely on generating antigen (Ag)-specific memory B cells and PCs for serological immunity.

Approach:

  • Human genetic studies of monogenic defects offer unique insights into immune cell function.
  • Analyzing individuals with inborn errors links genotypes to clinical phenotypes.
  • This approach elucidates critical pathways for B cell development and differentiation.

Key Points:

  • Inborn errors disrupting B cell function provide unprecedented models for studying human immunity.
  • Understanding these genetic defects is key to unraveling the complexities of humoral immunity.
  • Breakthroughs in this area link genetic mutations to impaired B cell differentiation and antibody production.

Conclusions:

  • Studying inborn errors of B cell function is crucial for understanding humoral immunity.
  • These genetic models help establish disease pathogenesis mechanisms.
  • Insights gained advance knowledge of immune cell development and host defense strategies.