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Small Cell Carcinoma of the Gallbladder
Snehasis Das1, Sagar Prakash1, Oseen Shaikh1
1Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND.
Cureus
|June 5, 2023
Summary
Primary neuroendocrine carcinoma of the gallbladder is a rare and aggressive cancer. Diagnosis often occurs at advanced stages, with palliative chemotherapy being the main treatment option.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Primary neuroendocrine carcinoma of the gallbladder (GB) is an exceptionally rare malignancy.
- This cancer carries a dismal prognosis and a fatal outcome.
Observation:
- A 45-year-old female presented with right upper quadrant abdominal pain and recurrent vomiting.
- Imaging revealed diffuse GB wall thickening, local invasion, extensive lymph node metastasis, and arteriovenous encasement.
Findings:
- Ultrasound-guided fine-needle aspiration confirmed small cell carcinoma of the GB.
- The patient was diagnosed at an advanced stage, necessitating palliative chemotherapy.
Implications:
- Small cell variant of GB neuroendocrine carcinoma is a rare, highly lethal entity.
- Limited treatment options are available for patients diagnosed at advanced stages.
- Palliative chemotherapy is the standard approach for managing this aggressive cancer.
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