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Role of High-Sensitivity C-reactive Protein Levels in Predicting the Risk of Six-Month Event Rates in Patients With
Ranjit K Nath1, Dheerendra Kuber1, Puneet Aggarwal1
1Cardiology, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia (RML) Hospital, New Delhi, IND.
Insights
High baseline high-sensitivity C-reactive protein (hs-CRP) levels are linked to increased angina and repeat revascularization after percutaneous transluminal coronary angioplasty (PTCA). However, no significant association was found with myocardial infarction or mortality in this study.
Area of Science:
- Cardiology
- Biomarkers
- Interventional Cardiology
Background:
- Symptomatic chronic stable angina poses a significant clinical challenge.
- Percutaneous transluminal coronary angioplasty (PTCA) with drug-eluting stents (DES) is a common intervention.
- The role of inflammatory markers like high-sensitivity C-reactive protein (hs-CRP) in predicting outcomes post-PCI requires further elucidation.
Purpose of the Study:
- To investigate the association between baseline hs-CRP levels and adverse cardiovascular events at six months post-PTCA with DES.
- To determine if hs-CRP levels can predict outcomes such as mortality, myocardial infarction, angina, or the need for repeat revascularization.
Main Methods:
- A prospective observational study involving 104 patients with symptomatic chronic stable angina undergoing PTCA with DES.
- Baseline hs-CRP levels were measured, categorizing patients into high and low hs-CRP groups.
- Patients were followed for six months to assess adverse events, including death, myocardial infarction, angina, and repeat revascularization.
Main Results:
- No significant differences in mortality or myocardial infarction were observed between high and low hs-CRP groups.
- Patients with high hs-CRP levels showed a significantly higher incidence of angina and a greater need for repeat revascularization compared to those with low hs-CRP.
- Baseline characteristics like age, gender, and comorbidities were similar between groups, except for dyslipidemia and smoking.
Conclusions:
- Elevated baseline hs-CRP is associated with an increased risk of angina and repeat revascularization following PTCA with DES.
- The current study did not establish a link between high baseline hs-CRP and myocardial infarction or mortality.
- Hs-CRP may serve as a useful biomarker for predicting specific adverse outcomes in patients undergoing coronary interventions.
Abstract:
Introduction This prospective observational study reports the association between baseline high-sensitivity C-reactive protein (hs-CRP) levels and adverse events at six months in patients who were diagnosed with symptomatic chronic stable angina and then underwent percutaneous transluminal coronary angioplasty (PTCA) with a drug-eluting stent (DES). Methods A total of 104 patients were examined with chronic stable angina over a period of six months. Before conducting percutaneous coronary intervention (PCI), the baseline levels of hs-CRP were measured, and based on the levels, the patients were grouped into high and low hs-CRP groups. Results The primary causes of death or the need for repeat revascularization or myocardial infarction or angina were concluded after assessing the patients for six months. A total of 104 patients were studied, among which 72 (69.23%) had low hs-CRP and 32 (30.77%) had high hs-CRP levels. The number of males in this study was 68 (65.38%) and females were 36 (34.62%). The mean age of the patients was 55.26 ± 10.31 years. There were no significant differences among the groups in terms of gender, age, comorbidities, and risk factors except for certain predisposing factors like dyslipidemia and smoking. Moreover, we did not find any significant difference among the groups in the cause of death and myocardial infarction after a follow-up of six months. However, we observed a higher need for revascularization and angina outcomes in the group with high hs-CRP compared to low hs-CRP. Conclusion It can be concluded that a higher risk of angina and repeat revascularization is related to a high baseline hs-CRP but there is no evidence whether it is somehow linked to myocardial infarction and mortality or not.
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