Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

In- and Out-Groups01:31

In- and Out-Groups

39.1K
People all belong to a gender, race, age, and social economic group. These groups provide a powerful source of our identity and self-esteem (Tajfel & Turner, 1979) and serve as our in-groups. An in-group is a group that we identify with or see ourselves as belonging to.
39.1K
In-situ Hybridization02:31

In-situ Hybridization

9.5K
In situ hybridization (ISH) is a technique used to detect and localize specific DNA or RNA molecules in cells, tissue, or tissue sections using a labeled probe. The technique was first used in 1969 for the investigation of nucleic acids. It is currently an essential tool in scientific research and clinical settings, especially for diagnostic purposes.
Types of probes and labels
A probe is a complementary strand of DNA or RNA that binds to corresponding nucleotide sequences in a cell. Many...
9.5K
Inductors01:11

Inductors

442
An inductor is a passive component built to store energy within its magnetic field. It can be fabricated by coiling a wire around a magnetic core. When current is permitted to flow through this inductor, it is observed that the voltage across the inductor is directly proportional to the time rate of change of the current. Mathematically,
442
Porin Insertion in the Outer Mitochondrial Membrane01:12

Porin Insertion in the Outer Mitochondrial Membrane

3.1K
Porins are beta-barrel proteins translocated to the mitochondrial outer membrane through the TOM complex into the intermembrane space. Porin precursors bind TIM chaperones within the intermembrane space and are guided to the Sorting and Assembly Machinery complex or SAM complex on the outer mitochondrial membrane.
Three models describe the assembly of porins by the SAM complex and their insertion into the outer membrane. Model 1 suggests that porins are assembled outside the SAM channel as the...
3.1K
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

14.0K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
14.0K
X-Inactivation01:58

X-Inactivation

38.8K
The human X chromosome contains over ten times the number of genes as in the Y chromosome. Since males have only one X chromosome, and females have two, one might expect females to produce twice as many of the proteins, with undesirable results.
38.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CT-based radiomics for predicting the treatment response to PD-1/PD-L1 inhibitors combined with chemotherapy in unresectable gastric cancer.

Insights into imaging·2026
Same author

Efficacy of polyethylene glycol in the treatment of spinal cord injury and its effect on inflammatory response and oxidative stress factors.

Frontiers in neurology·2026
Same author

Effects of Apigenin on the Apoptosis Index of Atherosclerosis.

Journal of cardiovascular pharmacology·2025
Same author

[Anti-tumor mechanism of traditional Chinese medicine via Hedgehog signaling pathway: a review].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2024
Same author

Implications of the NDC80 complex on the tumor immune microenvironment and cell growth in pan-cancer.

Journal of Cancer·2024
Same author

A radiomics signature derived from CT imaging to predict MSI status and immunotherapy outcomes in gastric cancer: a multi-cohort study.

BMC cancer·2024

Related Experiment Video

Updated: Jul 27, 2025

An in vivo Assay to Test Blood Vessel Permeability
07:03

An in vivo Assay to Test Blood Vessel Permeability

Published on: March 16, 2013

65.1K

In

Xue-Ling Yang1, Chun-Xuan Wang1, Jia-Xing Wang2

  • 1Department of Nephrology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Frontiers in Pharmacology
|June 5, 2023
PubMed
Summary

Prunella vulgaris may offer a natural treatment for COVID-19-associated acute kidney injury (AKI). Its compounds, like quercetin, show potential in silico by targeting key genes involved in the NF-κB pathway, suggesting a novel botanical therapy for kidney complications.

Keywords:
COVID-19acute kidney injurycytokine stormmolecular dockingnetwork pharmacology

More Related Videos

In vitro Induction of Human Dental Pulp Stem Cells Toward Pancreatic Lineages
07:32

In vitro Induction of Human Dental Pulp Stem Cells Toward Pancreatic Lineages

Published on: September 25, 2021

3.3K
In vivo and In vitro Rearing of Entomopathogenic Nematodes Steinernematidae and Heterorhabditidae
08:56

In vivo and In vitro Rearing of Entomopathogenic Nematodes Steinernematidae and Heterorhabditidae

Published on: September 22, 2014

20.6K

Related Experiment Videos

Last Updated: Jul 27, 2025

An in vivo Assay to Test Blood Vessel Permeability
07:03

An in vivo Assay to Test Blood Vessel Permeability

Published on: March 16, 2013

65.1K
In vitro Induction of Human Dental Pulp Stem Cells Toward Pancreatic Lineages
07:32

In vitro Induction of Human Dental Pulp Stem Cells Toward Pancreatic Lineages

Published on: September 25, 2021

3.3K
In vivo and In vitro Rearing of Entomopathogenic Nematodes Steinernematidae and Heterorhabditidae
08:56

In vivo and In vitro Rearing of Entomopathogenic Nematodes Steinernematidae and Heterorhabditidae

Published on: September 22, 2014

20.6K

Area of Science:

  • Herbal Medicine
  • Pharmacology
  • Bioinformatics

Background:

  • COVID-19-associated acute kidney injury (AKI) is a significant risk factor for mortality and chronic kidney disease.
  • Prunella vulgaris L., a traditional Chinese herb, has a history of treating kidney ailments.

Purpose of the Study:

  • To investigate the protective potential of Prunella vulgaris against COVID-19 AKI.
  • To explore the underlying mechanisms using network pharmacology and bioinformatics.

Main Methods:

  • Network pharmacology and bioinformatics analysis.
  • Protein-protein interaction network and enrichment analysis.
  • Molecular docking and dynamics simulations.

Main Results:

  • Identified eight key target genes (VEGFA, ICAM1, IL6, CXCL8, IL1B, CCL2, IL10, RELA).
  • Confirmed binding of quercetin, luteolin, and kaempferol to these targets.
  • Highlighted IL6, VEGFA, and RELA as potential targets inhibiting the NF-κB pathway.

Conclusions:

  • Prunella vulgaris and its compounds, particularly quercetin, show promise as botanical treatments for COVID-19 AKI.
  • The study provides in silico evidence for targeting the NF-κB pathway.
  • Further research is warranted to validate these findings in vivo.