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Everton Allan Ferreira1, Lucas Sales Queiroz1, Gabriella de Faria Silva Facchini2

  • 1Faculty of Pharmacy, Department of Pharmaceutical Sciences, Federal University of Juiz de Fora, Juiz de Fora, MG 36036-900, Brazil.

Evidence-Based Complementary and Alternative Medicine : Ecam
|June 5, 2023
PubMed
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Baccharis dracunculifolia root extract (BdR) and its compound baccharis oxide (BOx) show significant topical anti-inflammatory effects. These findings support their potential use in treating inflammatory skin conditions.

Area of Science:

  • Pharmacology
  • Natural Product Chemistry
  • Dermatology

Background:

  • Baccharis dracunculifolia is traditionally used for skin ailments.
  • Scientific validation of its anti-inflammatory properties is needed.

Purpose of the Study:

  • To evaluate the topical anti-inflammatory potential of B. dracunculifolia root extract (BdR) and baccharis oxide (BOx).
  • To investigate the mechanisms underlying the anti-inflammatory effects.

Main Methods:

  • Phytochemical analysis (GC-MS) of BdR to identify major compounds like BOx.
  • Topical application of BdR and BOx on mouse ear edema models (croton oil, capsaicin, histamine, phenol).
  • Assessment of biochemical markers (NAG, MPO, NO) and histopathological changes.

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Main Results:

  • BdR and BOx demonstrated significant reduction in edema induced by croton oil, histamine, and phenol.
  • BOx specifically inhibited capsaicin-induced edema.
  • Both BdR and BOx significantly reduced MPO and NAG activities and NO production.
  • Histopathological analysis confirmed the anti-inflammatory effects.

Conclusions:

  • BdR and BOx possess significant topical anti-inflammatory properties.
  • These compounds effectively mitigate various inflammatory responses in the skin.
  • Findings suggest potential therapeutic applications for inflammatory skin diseases.