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Mitochondrial Protease Targeting Chimeras for Mitochondrial Matrix Protein Degradation

Dachi Wang1,2, Wenxi Wang2,3, Le Fang2

  • 1School of Chemistry and Materials, University of Science and Technology of China, Hefei, Anhui 230026, China.

Journal of the American Chemical Society
|June 5, 2023
PubMed
Summary

Researchers developed a novel mitochondrial protease targeting chimera (MtPTAC) to degrade proteins within mitochondria. This breakthrough offers a new strategy for targeted protein degradation (TPD) in organelles lacking traditional degradation systems.

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