[Pancreatic duct occlusion compared with intraperitoneal secretion drainage after partial pancreatic resection in the...

One of the main problem for pancreatic transplantation and treatment of chronic pancreatitis is the handling of exocrine secretion. We compared in an experimental study pancreatic segments in dogs after removing the right lobe of the pancreas with free drainage of exocrine secretion into the peritoneal cavity, duct occlusion with Ethibloc or Neoprene. The lowest complication rate was seen in group with open duct technique. Plasma glucose levels was normally in all groups without significant differences. The pattern of blood glucose after the intravenous administration of 0.5 g glucose/kg was characterized by an assimilation coefficient (k-value) which was significantly (p less than 0.05) higher for open duct and Ethibloc than in Neoprene dogs. Peak insulin values appeared delayed and significant lower than in normal control group. Histologically was at first seen an oedema in all groups. The occlusion of the pancreatic duct specially in Neoprene dogs resulted in a marked interstitial progressive fibrosis. The substance Ethibloc was totally reabsorbed after the 10th day.