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Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography
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Mendelian randomization supports causality between overweight status and accelerated aging.

Zong Chen1, Zhiyou Chen2, Xiaolei Jin1

  • 116th Department, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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Overweight is causally linked to accelerated aging, evidenced by shorter telomere length, increased frailty, and faster facial aging. This also correlates with reduced longevity expectancy, highlighting the importance of weight management.

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Area of Science:

  • Genetics and Aging Research
  • Metabolic Health and Longevity

Background:

  • Overweight is suspected to accelerate aging, but direct causal evidence is limited.
  • Aging is a complex process influenced by various factors, including metabolic status.

Purpose of the Study:

  • To investigate the causal effect of overweight on indicators of accelerated aging.
  • To explore the relationship between overweight and longevity expectancy using genetic data.

Main Methods:

  • Utilized Mendelian Randomization (MR) analyses with genetic variants associated with overweight and aging proxies.
  • Employed inverse variance weighted method, sensitivity, and validation analyses for robust results.
  • Analyzed data from genome-wide association studies for genetic associations.

Main Results:

  • Confirmed significant causal associations between overweight and accelerated aging indicators: decreased telomere length, increased frailty index, and enhanced facial aging.
  • Demonstrated a significant negative causal effect of overweight on longevity expectancy at the 90th and 99th survival percentiles.
  • Found evidence supporting causal links between body fat mass/percentage and aging proxies, but not body fat-free mass.

Conclusions:

  • This study provides robust evidence for the causal role of overweight in accelerating biological aging processes.
  • Overweight is causally associated with reduced longevity expectancy.
  • Weight control and overweight treatment are crucial for mitigating accelerated aging and improving lifespan.