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Updated: Jul 27, 2025

Author Spotlight: Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates
Published on: May 12, 2023
The C3 conundrum
Maria Lean1, Bobby Chacko1,2
1Nephrology and Transplantation Unit, John Hunter Hospital, Newcastle, New South Wales, Australia.
Abstract:
A 62-year-old man with nephritic syndrome underwent a kidney biopsy which revealed a C3 dominant pattern on immunofluorescence. A diagnosis of C3 glomerulopathy (C3G) was suspected. However, a recent skin infection and high levels of anti-streptococcal antibodies were indicative of post-infectious glomerulonephritis (PIGN). This paper compares PIGN and C3G and describes an atypical form of PIGN with alternative complement pathway dysregulation.
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